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Decoupling SARS-CoV-2 ORF6 localization and interferon antagonism

21 Feb 2022

Abstract excerpt

Like many pathogenic viruses, SARS-CoV-2 must overcome interferon (IFN)-mediated host defenses for infection establishment. To achieve this, SARS-CoV-2 deploys overlapping mechanisms to antagonize IFN production and signaling. The strongest IFN antagonist is the accessory protein ORF6, which localizes to multiple membranous compartments, including the nuclear envelope, where it directly binds nuclear pore...

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PMID: 35187564
DOI: 10.1242/jcs.259666

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