Article

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

2022-10-19

Abstract excerpt

<h4>ABSTRACT</h4> We and others have previously shown that the SARS-CoV-2 accessory protein ORF6 is a powerful antagonist of the interferon (IFN) signaling pathway by directly interacting with Nup98-Rae1 at the nuclear pore complex (NPC) and disrupting bidirectional nucleo-cytoplasmic trafficking. In this study, we further assessed the role of ORF6 during infection using recombinant SARS-CoV-2 viruses carrying ei...

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Literature Corpus work: 3c0248cd-9660-5350-8413-34c607298217
DOI: 10.1101/2022.10.18.512708

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