Article

Decoupling SARS-CoV-2 ORF6 localization and interferon antagonism

2021-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Like many pathogenic viruses, SARS-CoV-2 must overcome interferon (IFN)-mediated host defenses for infection establishment. To achieve this, SARS-CoV-2 deploys overlapping mechanisms to antagonize IFN production and signaling. The strongest IFN antagonist is the accessory protein ORF6, which localizes to multiple membranous compartments, including the nuclear envelope, where it directly binds th...

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Literature Corpus work: 39784eb7-77ce-5155-b8f0-1a3c222da148
DOI: 10.1101/2021.12.06.471415

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