Article

Structures of microRNA-precursor apical junctions and loops reveal non-canonical base pairs important for processing

2020-05-05

Abstract excerpt

Metazoan pri-miRNAs and pre-miRNAs fold into characteristic hairpins that are recognized by the processing machinery. Essential to the recognition of these miR-precursors are their apical junctions where double-stranded stems meet single-stranded hairpin loops. Little is known about how apical junctions and loops fold in three-dimensional space. Here we developed a scaffold-directed crystallography method and dete...

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Literature Corpus work: 5e8b6dd5-d944-5d23-83a3-36b15bed153d
DOI: 10.1101/2020.05.05.078014

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