Article

Fe(III) heme sets an activation threshold for processing distinct groups of pri-miRNAs in mammalian cells

2020-02-19

Abstract excerpt

<h4>ABSTRACT</h4> The essential biological cofactor heme is synthesized in cells in the Fe(II) form. Oxidized Fe(III) heme is specifically required for processing primary transcripts of microRNAs (pri-miRNAs) by the RNA-binding protein DGCR8, a core component of the Microprocessor complex. It is unknown how readily available Fe(III) heme is in the largely reducing environment in human cells and how changes in cel...

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Identifiers and source

Literature Corpus work: 177eb368-378c-5a55-b450-698fdb01c34f
DOI: 10.1101/2020.02.18.955294

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