Article

Structural differences between pri-miRNA paralogs promotes alternative Drosha cleavage and expands target repertoires

2018-07-10

Abstract excerpt

MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the maturation of three pri-miR-9 paralogs, which encode the same mature miRNA but differ in the surrounding scaffold. We show that pri-miR-9-1 has a unique Drosha cleavage p...

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Literature Corpus work: a22b912c-84cf-5cfc-b531-7fd570fc0df5
DOI: 10.1101/366492

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