Article

The structural landscape of Microprocessor mediated pri- <i>let-7</i> miRNA processing

2024-05-09

Abstract excerpt

<h4>Summary</h4> miRNA biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase III enzyme and its partner DGCR8. Multiple pri-miRNA sequence motifs affect MP recognition, fidelity, and efficiency. Here, we performed cryo-EM and biochemical studies of several let-7 family pri-miRNAs in complex with human MP. We show that MP has the struc...

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Literature Corpus work: eaf7f6a2-3746-53b2-bacc-9a7f7b8cedd7
DOI: 10.1101/2024.05.09.593372

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