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Article

Structural insights into disease-associated mutations in the microRNA processing machinery.

Experimental & molecular medicine - 1 Mar 2026

Lee Hansol, Lee Jaehyun, Roh Soung-Hun

Abstract excerpt

MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene silencing through a conserved pathway involving the sequential actions of DROSHA, DICER and Argonaute proteins. These RNA interference core components recognize and process precursor transcripts with structural precision to generate functional miRNA duplexes and guide-loaded Argonaute effector complexes. Recent genetic and...

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Share to Argonaute Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonuclease III

Share to RNA Processing, Post-Transcriptional

Source

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Identifiers

PMID: 41792231
DOI: 10.1038/s12276-026-01669-4
PMCID: PMC13049099

Genes

DICER1
DROSHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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