Structural features within precursor microRNA-20a regulate Dicer-TRBP processing

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miRNA expression levels, the enzymatic processing of primary and precursor miRNA elements must be strictly controlled. However, the molecular determinants underlying this strict regulation of miRNA biogenesis are not fully understood. Here, we determined the solution st...

Topics

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• Heterogeneous Nuclear Ribonucleoprotein A1
• Nuclear Magnetic Resonance, Biomolecular
• Nucleic Acid Conformation
• Ribonuclease III
• RNA-Binding Proteins
• RNA Processing, Post-Transcriptional
• Serine-Arginine Splicing Factors
• Single Molecule Imaging

Identifiers and source

Literature Corpus work

0a1eaca7-7414-5709-9e73-41834981f378

DOI

10.1101/2025.05.07.652689