Article

Human Precursor microRNA Terminal Loop Regions Exhibit Distinct Sequence Characteristics and Motif Enrichment

2026-07-24

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that modulate diverse biological processes and are implicated in numerous diseases, including cancer. The terminal loop (TL) of precursor miRNAs (pre-miRNAs) is a key determinant of miRNA biogenesis, influencing both processing efficiency and interactions with RNA-binding proteins (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d006fb04-561b-5f35-ab7e-d43a1ec8be76
DOI: 10.21203/rs.3.rs-10460512/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Precursor microRNA Terminal Loop Regions Exhibit Distinct Sequence Characteristics and Motif EnrichmentDOI 10.21203/rs.3.rs-10460512/v1Read

Tumor Suppression across the Human miRNome Associates with Guanine-Rich Precursor Terminal LoopsSemantic proximity Read

Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation.Semantic proximity Read

Identification of loop nucleotide polymorphisms affecting microRNA processing and function.Semantic proximity Read

MiREDiBase: a manually curated database of validated and putative editing events in microRNAsSemantic proximity Read

Functional and evolutionary significance of human microRNA seed region mutations.Semantic proximity Read

miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.Semantic proximity Read

The terminal loop region controls microRNA processing by Drosha and Dicer.Semantic proximity Read

Bioinformatic tools for microRNA dissection.Semantic proximity Read

Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA StabilitySemantic proximity Read

Structures of microRNA-precursor apical junctions and loops reveal non-canonical base pairs important for processingSemantic proximity Read

The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation.Semantic proximity Read

Widespread separation of the polypyrimidine tract from 3’ AG by G tracts in association with alternative exons in metazoa and plantsSemantic proximity Read