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Article

G-Quadruplexes influence pri-microRNA processing.

RNA biology - 1 Feb 2018

Rouleau Samuel G, Garant Jean-Michel, Bolduc François, Bisaillon Martin, Perreault Jean-Pierre

Abstract excerpt

RNA G-Quadruplexes (G4) have been shown to possess many biological functions, including the regulation of microRNA (miRNA) biogenesis and function. However, their impact on pri-miRNA processing remains unknown. We identified G4 located near the Drosha cleavage site in three distinct pri-miRNAs: pri-mir200c, pri-mir451a, and pri-mir497. The folding of the potential G4 motifs was determined in solution....

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Identifiers

PMID: 29171334
DOI: 10.1080/15476286.2017.1405211
PMCID: PMC5798953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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