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Article

Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation.

Genome research - 1 Mar 2017

Roden Christine, Gaillard Jonathan, Kanoria Shaveta, Rennie William, Barish Syndi, Cheng Jijun, Pan Wen, Liu Jun, Cotsapas Chris, Ding Ye, Lu Jun

Abstract excerpt

Mature microRNAs (miRNAs) are processed from hairpin-containing primary miRNAs (pri-miRNAs). However, rules that distinguish pri-miRNAs from other hairpin-containing transcripts in the genome are incompletely understood. By developing a computational pipeline to systematically evaluate 30 structural and sequence features of mammalian RNA hairpins, we report several new rules that are preferentially utilized in...

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Identifiers

PMID: 28087842
DOI: 10.1101/gr.208900.116
PMCID: PMC5340965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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