Article

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

2021-08-18

Abstract excerpt

<h4>SUMMARY</h4> Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of endogenous pri-miRNAs and their variants both in vitro and in vivo . We show that, in addition to previ...

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Literature Corpus work: 205362a6-2b93-54e1-9c8b-4f9bff22afa8
DOI: 10.1101/2021.08.18.456839

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