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Article

Structure of the human DICER-pre-miRNA complex in a dicing state.

Nature - 1 Mar 2023

Lee Young-Yoon, Lee Hansol, Kim Haedong, Kim V Narry, Roh Soung-Hun

Abstract excerpt

Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs (dsRNAs)1,2. Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards long dsRNAs-unlike its homologues in lower eukaryotes and plants, which cleave long dsRNAs. Although the mechanism by which long dsRNAs are cleaved has...

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Identifiers

PMID: 36813958
DOI: 10.1038/s41586-023-05723-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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