Article

DeCiFering the Elusive Cancer Cell Fraction in Tumor Heterogeneity and Evolution

2021-02-27

Abstract excerpt

Most tumors are heterogeneous mixtures of normal cells and cancer cells, with individual cancer cells distinguished by somatic mutations that accumulated during the evolution of the tumor. The fundamental quantity used to measure tumor heterogeneity from somatic single-nucleotide variants (SNVs) is the Cancer Cell Fraction (CCF), or proportion of cancer cells that contain the SNV. However, in tumors containing cop...

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Literature Corpus work: 5e850785-5e86-56b9-969b-6e47977eb436
DOI: 10.1101/2021.02.27.429196

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