Article

SECEDO: SNV-based subclone detection using ultra-low coverage single-cell DNA sequencing

2021-11-09

Abstract excerpt

<h4>Motivation</h4> Several recently developed single-cell DNA sequencing technologies enable whole-genome sequencing of thousands of cells. However, the ultra-low coverage of the sequenced data ( < 0.05x per cell) mostly limits their usage to the identification of copy number alterations in multi-megabase segments. Many tumors are not copy number-driven, and thus single-nucleotide variant (SNV)-based subclone d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 994bb79a-be82-5e73-a4fe-2c60fb5d9df0
DOI: 10.1101/2021.11.08.467510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SECEDO: SNV-based subclone detection using ultra-low coverage single-cell DNA sequencingDOI 10.1101/2021.11.08.467510Read

SECEDO: SNV-based subclone detection using ultra-low coverage single-cell DNA sequencing.Semantic proximity Read

Assessing the Performance of Methods for Cell Clustering from Single-cell DNA Sequencing DataSemantic proximity Read

<i>BiTSC</i> 2: Bayesian inference of tumor clonal tree by joint analysis of single-cell SNV and CNA dataSemantic proximity Read

SC-BIG: A Hierarchical Bayesian Model for Bulk-Informed Single Nucleotide Variant Calling in Single CellsSemantic proximity Read

Accurate de novo detection of somatic mutations in high-throughput single-cell profiling data setsSemantic proximity Read

Resolving single-cell copy number profiling for large datasetsSemantic proximity Read

Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing dataSemantic proximity Read

Accurate <i>de novo</i> detection of somatic mutations in high-throughput single-cell profiling data setsSemantic proximity Read

Principles of Reconstructing the Subclonal Architecture of Cancers.Semantic proximity Read

Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumorsSemantic proximity Read

Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing dataSemantic proximity Read

SCANBIT facilitates identification of tumor cell populations in scRNAseq data using pseudobulked SNV callsSemantic proximity Read