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Article

DeCiFering the elusive cancer cell fraction in tumor heterogeneity and evolution.

Cell systems - 20 Oct 2021

Satas Gryte, Zaccaria Simone, El-Kebir Mohammed, Raphael Benjamin J

Abstract excerpt

The cancer cell fraction (CCF), or proportion of cancerous cells in a tumor containing a single-nucleotide variant (SNV), is a fundamental statistic used to quantify tumor heterogeneity and evolution. Existing CCF estimation methods from bulk DNA sequencing data assume that every cell with an SNV contains the same number of copies of the SNV. This assumption is unrealistic in tumors with copy-number aberrations...

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Source

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Identifiers

PMID: 34416171
DOI: 10.1016/j.cels.2021.07.006
PMCID: PMC8542635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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