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Article

Principles of Reconstructing the Subclonal Architecture of Cancers.

Cold Spring Harbor perspectives in medicine - 1 Aug 2017

Dentro Stefan C, Wedge David C, Van Loo Peter

Abstract excerpt

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor's subclonal composition through the identification of populations of cells with shared mutations. We describe the principles that...

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Share to Algorithms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

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Identifiers

PMID: 28270531
DOI: 10.1101/cshperspect.a026625
PMCID: PMC5538405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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