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Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App NL-G-F knock-in mouse model of the earliest phase of Alzheimer’s disease

2024-08-10

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Genome-wide association studies (GWAS) have identified a transcriptional network of Alzheimer’s disease (AD) risk genes that are primarily expressed in microglia and are associated with AD pathology. However, traditional short-read sequencers have limited our ability to fully characterize how GWAS variants exert their effects on gene expression regulation or alternative splicing in response to the pathology, parti...

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Literature Corpus work: bddeb319-0c40-5e6e-b608-9fb12a73c9bb
DOI: 10.1101/2024.08.10.607237

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Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the <i> App <sup>NL-G-F</sup> </i> knock-in mouse model of the earliest phase of Alzheimer’s disease

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