Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of the cellular prion protein on amyloid-β and 3PO-tau processing.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Schmitz Matthias, Wulf Katharina, Signore Sandra C, Schulz-Schaeffer Walter J, Kermer Pawel, Bähr Mathias, Wouters Fred S, Zafar Saima, Zerr Inga

Abstract excerpt

Previous studies indicate an important role for the cellular prion protein (PrP(C)) in the development of Alzheimer's disease (AD) pathology. In the present study, we analyzed the involvement of PrP(C) in different pathological mechanisms underlying AD: the processing of the amyloid-β protein precursor (AβPP) and its interaction with AβPP, tau, and different phosphorylated forms of the tau protein (p-tau). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to HEK293 Cells

Share to Neuroblastoma

Share to Prions

Share to tau Proteins

Source

Identifiers

PMID: 24028865
DOI: 10.3233/JAD-130566

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the cellular prion protein on amyloid-β and 3PO-tau processing.PMID 24028865Read ↗

Role of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer’s Disease EvolutionSemantic proximity Read ↗

Prion protein and agingSemantic proximity Read ↗

Physiological Role of the Cellular Prion Protein (PrP<sup>c</sup>): Protein Profiling Study in Two Cell Culture SystemsSemantic proximity Read ↗

Prion protein and prion disease at a glanceSemantic proximity Read ↗

Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation.Semantic proximity Read ↗

The multiple functions of PrPC in physiological, cancer, and neurodegenerative contextsSemantic proximity Read ↗

Tau oligomers impair memory and synaptic plasticity through the cellular prion proteinSemantic proximity Read ↗

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer’s Knock-in Mice Require Cellular Prion ProteinSemantic proximity Read ↗

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.Semantic proximity Read ↗

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.Semantic proximity Read ↗

Stress-protective signalling of prion protein is corrupted by scrapie prions.Semantic proximity Read ↗

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.