Article

Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.

2022-04-20

Abstract excerpt

<title>Abstract</title> <bold>BACKGROUND:</bold> A rare coding variant, <italic>P522R,</italic> in the phosphoplipase C gamme 2 (<italic>PLCG2)</italic> gene has been identified as protective against late onset Alzheimer’s disease (AD), but the mechanism is unknown. <italic>PLCG2</italic> is exclusively expressed in microglia within the central nervous sytem, and altered microglial function has been implicated...

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Literature Corpus work: c7e1be48-5c90-5183-80bc-060eac875c46
DOI: 10.21203/rs.3.rs-1420006/v2

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