Article

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

2022-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Genome-Wide Association Studies revealed the TREM2 R47H variant as one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current TREM2 *R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that produces a confounding reduction in protein product. We have developed the Trem2 R47H NSS ( N ormal S plice S ite) mouse...

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Literature Corpus work: b25f50eb-5d65-5575-81b4-0c90b24e72ca
DOI: 10.1101/2022.03.09.483490

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