Article

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice

2025-04-02

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and synaptic and neuronal loss. Recently, a rare autosomal dominant coding mutation, T835M, in the Un-coordinated 5c (UNC5C) netrin receptor gene was segregated with late-onset AD (LOAD). Overexpression of T835M in primary hippocampal neurons increased cell death in response to neurotoxic stimuli incl...

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Literature Corpus work: 186d3e75-afa7-59a5-ac4c-c9df16ec47aa
DOI: 10.21203/rs.3.rs-5462618/v1

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