Article

Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer

2020-10-25

Abstract excerpt

Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin remodeling, yet little is known about the interplay between these two classes of events in shaping the clonal diversity of cancers. We present Alleloscope, a method for allele-specific copy number estimation that can be applied to single cell DNA and ATAC sequencing data, either separately or in combination. This approach all...

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Literature Corpus work: dd208382-4076-5f3d-93c6-18491430ab2e
DOI: 10.1101/2020.10.23.349407

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