Article

Motif Disruption Domains Lead To Cancer Gene Expression Rewiring

2017-04-11

Abstract excerpt

Somatic mutations accumulate in non-coding regions of the genome during tumorigenesis, but their functional characterization presents a challenge. Somatic non-coding mutations rarely overlap among patients, which necessitates large sample sizes to detect associations. We analysed somatic mutations called from whole-genome sequencing (WGS) and RNA sequencing (RNAseq) from 3000 tumors across the Pan-Cancer Analysis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 253312eb-9b90-5c3d-af2e-90c9e0c34ee3
DOI: 10.1101/126359

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Motif Disruption Domains Lead To Cancer Gene Expression RewiringDOI 10.1101/126359Read

Systematic identification of significantly mutated regions reveals a rich landscape of functional molecular alterations across cancer genomesSemantic proximity Read

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome.Semantic proximity Read

Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.Semantic proximity Read

Pan-cancer discovery of driver mutations in long noncoding RNAs reveals widespread functional rewiring of RNA regulatory elementsSemantic proximity Read

Genome-wide hyper-mutated genes and hotspot detection across 27 cancersSemantic proximity Read

Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networksSemantic proximity Read

A pan-cancer landscape of somatic substitutions in non-unique regions of the human genomeSemantic proximity Read

CNCDatabase: a database of non-coding cancer driversSemantic proximity Read

Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles.Semantic proximity Read

Functional annotation of noncoding mutations in cancer.Semantic proximity Read

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancersSemantic proximity Read

Annotations of Recurrent Structural Variant Events in Pan-cancer Whole Genome Data for Precision MedicineSemantic proximity Read