Article

Process-specific somatic mutation distributions vary with three-dimensional genome structure

2018-09-25

Abstract excerpt

Somatic mutations arise during the life history of a cell. Mutations occurring in cancer driver genes may ultimately lead to the development of clinically detectable disease. Nascent cancer lineages continue to acquire somatic mutations throughout the neoplastic process and during cancer evolution (Martincorena and Campbell, 2015). Extrinsic and endogenous mutagenic factors contribute to the accumulation of these...

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Literature Corpus work: 788b5432-b6c6-5429-84be-e937622658bc
DOI: 10.1101/426080

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