Article

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

2018-05-05

Abstract excerpt

<h4>SUMMARY</h4> Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin and drivers of ITH across cancer types are poorly understood. To address this question, we extensively characterize ITH across whole-genome sequences of 2,658 cancer samples, spanning 38 cancer types. Nearly all informative samples (95.1%) contain evi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ab7d448-c47a-51d7-bb5b-555662986f15
DOI: 10.1101/312041

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomesDOI 10.1101/312041Read

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.Semantic proximity Read

A large-scale snapshot of intratumor heterogeneity in human cancer.Semantic proximity Read

Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival.Semantic proximity Read

CancerTracer: a curated database for intrapatient tumor heterogeneity.Semantic proximity Read

The intra-tumour heterogeneity landscape of human cancersSemantic proximity Read

Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancersSemantic proximity Read

The whole-genome panorama of cancer driversSemantic proximity Read

Pan-cancer whole genome comparison of primary and metastatic solid tumorsSemantic proximity Read

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.Semantic proximity Read

Pan-cancer whole genome analyses of metastatic solid tumorsSemantic proximity Read

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instabilitySemantic proximity Read

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.Semantic proximity Read