Article

A pan-cancer landscape of somatic substitutions in non-unique regions of the human genome

2020-04-15

Abstract excerpt

Around 13% of the human genome displays high sequence similarity with at least one other chromosomal position and thereby poses challenges for computational analyses such as detection of somatic events in cancer. We here extract features of sequencing data from across non-unique regions and employ a machine learning pipeline to describe a landscape of somatic substitutions in 2,658 cancers from the PCAWG cohort. W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b476669-210b-5863-9170-1b84f333236e
DOI: 10.1101/2020.04.14.040634

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A pan-cancer landscape of somatic substitutions in non-unique regions of the human genomeDOI 10.1101/2020.04.14.040634Read

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome.Semantic proximity Read

COSMIC: exploring the world's knowledge of somatic mutations in human cancer.Semantic proximity Read

Landscape of human protein-coding somatic mutations across tissues and individualsSemantic proximity Read

Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patientsSemantic proximity Read

SomaMutDB 2.0: A comprehensive database for exploring somatic mutations and their functional impact in normal human tissuesSemantic proximity Read

Germline determinants of the somatic mutation landscape in 2,642 cancer genomesSemantic proximity Read

Emerging patterns of somatic mutations in cancer.Semantic proximity Read

Origins and characterization of variants shared between databases of somatic and germline human mutations.Semantic proximity Read

Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types.Semantic proximity Read

Evolutionary signatures of human cancers revealed via genomic analysis of over 35,000 patientsSemantic proximity Read

Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes.Semantic proximity Read

The somatic mutation landscape of the human bodySemantic proximity Read