Article

Topography of mutational signatures in human cancer

2022-05-29

Abstract excerpt

<h4>SUMMARY</h4> The somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can be affected by the genome architecture. However, the interplay between mutational signatures and topographical genomic features has not been extensively explored. Here, we integrate mutations from 5,120 whole-genome sequenced tumour...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb71672f-8e48-55d8-94e5-7b8c844c7dab
DOI: 10.1101/2022.05.29.493921

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Topography of mutational signatures in human cancerDOI 10.1101/2022.05.29.493921Read

Topography of mutational signatures in human cancer.Semantic proximity Read

The Repertoire of Mutational Signatures in Human CancerSemantic proximity Read

Chromatin accessibility of primary human cancers ties regional mutational processes with tissues of originSemantic proximity Read

The shaping of cancer genomes with the regional impact of mutation processes.Semantic proximity Read

Regional Mutational Signature Activities in Cancer GenomesSemantic proximity Read

Topographical archetypes of somatic mutagenesis in cancerSemantic proximity Read

Regional mutational signature activities in cancer genomes.Semantic proximity Read

Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin.Semantic proximity Read

Mutational landscape and significance across 12 major cancer types.Semantic proximity Read

Clinical and genomic characterization of mutational signatures across human cancers.Semantic proximity Read

The repertoire of mutational signatures in human cancer.Semantic proximity Read

Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes.Semantic proximity Read