Article

Longitudinal increase of CSF soluble TREM2 is driven by early aggregation of Aβ42 and associates with slower amyloid deposition and clinical decline in autosomal-dominant Alzheimer’s disease

2021-07-31

Abstract excerpt

<title>Abstract</title> <p>Therapeutic modulation of TREM2-dependent microglial function provides an additional strategy to slow progression of Alzheimer disease (AD). Although studies on animal models suggest that TREM2 is protective, the trigger of increased TREM2 expression during disease progression and its clinical and pathological consequences in AD remain unclear. We measured longitudinally soluble TREM2 (...

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Literature Corpus work: 5d6204f5-563f-5446-b217-73ef92bc593f
DOI: 10.21203/rs.3.rs-744827/v1

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Longitudinal increase of CSF soluble TREM2 is driven by early aggregation of Aβ42 and associates with slower amyloid deposition and clinical decline in autosomal-dominant Alzheimer’s diseaseDOI 10.21203/rs.3.rs-744827/v1Read

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