Article

APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies

2026-07-31

Abstract excerpt

<title>Abstract</title> <p> Dementia with Lewy bodies (DLB) is characterized by marked biological heterogeneity, only partly explained by the frequent presence of Alzheimer’s disease (AD) copathology. Whether microglial responses contribute to this heterogeneity and how they are modulated by APOE genotype remain poorly understood. Using a specific immunoassay targeting cleaved soluble TREM2 (sTREM2), we investig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c061165-7410-59a9-b67c-247f117b5a17
DOI: 10.21203/rs.3.rs-10429506/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodiesDOI 10.21203/rs.3.rs-10429506/v1Read

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.Semantic proximity Read

Longitudinal increase of CSF soluble TREM2 is driven by early aggregation of Aβ42 and associates with slower amyloid deposition and clinical decline in autosomal-dominant Alzheimer’s diseaseSemantic proximity Read

CSF Soluble TREM2 Concentrations Correlate With the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s DiseaseSemantic proximity Read

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers diseaseSemantic proximity Read

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupSemantic proximity Read

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.Semantic proximity Read

Associations Between TREML2 Gene Variants and Alzheimer's Disease: Biomarkers, Neuroimage, and Cognition.Semantic proximity Read

Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.Semantic proximity Read

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Semantic proximity Read

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.Semantic proximity Read

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.Semantic proximity Read

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.Semantic proximity Read