Article

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers disease

2025-08-12

Abstract excerpt

<h4>Background: </h4> CSF and blood soluble TREM2 (sTREM2) levels have been found to increase at early stage of Alzheimers Disease (AD), albeit plasma levels have been inconclusive. Alterations to AD-related blood biomarkers and brain amyloid beta (Abeta) load remain unclear. How R47H/R62H rare variants in TREM2 gene associated with increased risk of AD may affect plasma sTREM2 has not been reported. <h4>Objective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37a5c686-6cb5-5a60-8872-a507f3e52b41
DOI: 10.1101/2025.08.11.25333037

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers diseaseDOI 10.1101/2025.08.11.25333037Read

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Semantic proximity Read

CSF Soluble TREM2 Concentrations Correlate With the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s DiseaseSemantic proximity Read

Longitudinal increase of CSF soluble TREM2 is driven by early aggregation of Aβ42 and associates with slower amyloid deposition and clinical decline in autosomal-dominant Alzheimer’s diseaseSemantic proximity Read

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupSemantic proximity Read

APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodiesSemantic proximity Read

The <i>MS4A</i> gene cluster is a key regulator of soluble TREM2 and Alzheimer disease riskSemantic proximity Read

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.Semantic proximity Read

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s diseaseSemantic proximity Read

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.Semantic proximity Read

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.Semantic proximity Read

Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid-soluble TREM2.Semantic proximity Read

Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.Semantic proximity Read