Article
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
Acta neuropathologica - 1 Jun 2016
Piccio Laura, Deming Yuetiva, Del-Águila Jorge L, Ghezzi Laura, Holtzman David M, Fagan Anne M, Fenoglio Chiara, Galimberti Daniela, Borroni Barbara, Cruchaga Carlos
Abstract excerpt
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early-onset dementia, named Nasu-Hakola disease (NHD). TREM2 can be detected as a soluble protein in cerebrospinal fluid (CSF) and plasma, and its CSF levels are elevated in inflammatory CNS diseases. We measured soluble TREM2 (sTREM2) in...
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