Article

TREM2 limits progression of deficits and spreading of tau pathology in mice

2022-09-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Amyloid-β (Aβ) and tau form pathogenic lesions in Alzheimer’s disease (AD) brains. As ΑD clinically progresses, tau pathology propagates in a very distinct pattern between connected brain areas. The molecular mechanisms underlying this tau pathology spread remain largely unknown. Genome-wide association studies have identified polymorphisms in <italic>triggering...

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Literature Corpus work: cd364d25-856b-5a72-83da-a45ce179c1da
DOI: 10.21203/rs.3.rs-741896/v2

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