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Article

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.

Science translational medicine - 14 Dec 2016

Suárez-Calvet Marc, Araque Caballero Miguel Ángel, Kleinberger Gernot, Bateman Randall J, Fagan Anne M, Morris John C, Levin Johannes, Danek Adrian, Ewers Michael, Haass Christian

Abstract excerpt

Emerging evidence supports a role for innate immunity and microglia in Alzheimer's disease (AD) pathophysiology. However, no marker related to microglia has been included in the temporal evolution models of AD. TREM2 is a transmembrane protein involved in innate immunity and is selectively expressed by microglia and genetically linked to AD and other neurodegenerative disorders. Its ectodomain is released by...

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Identifiers

PMID: 27974666
DOI: 10.1126/scitranslmed.aag1767
PMCID: PMC5385711

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.PMID 27974666Read ↗

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