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Article

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Molecular neurodegeneration - 8 Oct 2020

Franzmeier Nicolai, Suárez-Calvet M, Frontzkowski Lukas, Moore Annah, Hohman Timothy J, Morenas-Rodriguez Estrella, Nuscher Brigitte, Shaw Leslie, Trojanowski John Q, Dichgans Martin, Kleinberger Gernot, Haass Christian, Ewers Michael

Abstract excerpt

BACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a central role in microglia activation in response to AD brain pathologies. Whether higher TREM2-related microglia activity modulates the risk to develop clinical AD...

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Identifiers

PMID: 33032659
DOI: 10.1186/s13024-020-00407-2
PMCID: PMC7545547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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