Article

European-derived coronary artery disease polygenic scores over-flag genetic risk in Vietnamese and Southeast Asian populations: a multi-score analysis in 1000 Genomes

2026-07-15

Abstract excerpt

<h4>Background</h4> Polygenic scores (PRS) for coronary artery disease (CAD) are derived almost entirely from European-ancestry data. Their portability to Southeast Asian populations, including the Vietnamese, is largely uncharacterised and clinically consequential when scores are used with risk thresholds. <h4>Methods</h4> We evaluated four independent European-derived CAD scores from the PGS Catalog (PGS000058...

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Literature Corpus work: 5c976a85-87e2-577f-873a-7bfb51a4e163
DOI: 10.64898/2026.07.10.26357796

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