Article
Population Bias in Polygenic Risk Prediction Models for Coronary Artery Disease.
Circulation. Genomic and precision medicine - 1 Dec 2020
Gola Damian, Erdmann Jeanette, Läll Kristi, Mägi Reedik, Müller-Myhsok Bertram, Schunkert Heribert, König Inke R
Abstract excerpt
BACKGROUND: Individual risk prediction based on genome-wide polygenic risk scores (PRSs) using millions of genetic variants has attracted much attention. It is under debate whether PRS models can be applied-without loss of precision-to populations of similar ethnic but different geographic background than the one the scores were trained on. Here, we examine how PRS trained in population-specific but European data...
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