Article

Integrating polygenic and transcriptional risk scores improves risk prediction of nine common diseases in the underrepresented Vietnamese population

2025-12-09

Abstract excerpt

Polygenic risk scores (PRS) represent the cumulative impact of numerous common genomic variants, to predict clinical phenotypes and outcomes for individuals. However, PRS are typically derived from GWAS for populations of European origin, often resulting in reduced performance and their transferability to other underserved populations. In this study, we comprehensively analyzed 550 samples for nine common diseases...

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Literature Corpus work: 5bb20774-7c0d-5407-9b59-f5110f183c63
DOI: 10.64898/2025.12.08.25341869

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