Article

Mechanism of human tRNA 3’CCA maturation

2026-03-03

Abstract excerpt

<h4>Summary</h4> The non-templated addition of the 3’CCA end is the final universal step of tRNA maturation. In humans, 3’CCA addition on nuclear- (nu-tRNA) and mitochondria-encoded tRNAs (mt-tRNA) is catalyzed by a single CCA-adding enzyme, TRNT1, but its precise mechanism remains unknown. Here, we report structures of TRNT1 trapped at various stages during the 3’CCA addition cycle on canonical and non-canonical...

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Literature Corpus work: 5c4461f4-11fc-5858-a263-6af3129ec9ff
DOI: 10.64898/2026.03.02.709036

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