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Article

Molecular basis for t6A modification in human mitochondria.

Nucleic acids research - 6 Apr 2020

Zhou Jing-Bo, Wang Yong, Zeng Qi-Yu, Meng Shi-Xin, Wang En-Duo, Zhou Xiao-Long

Abstract excerpt

N 6-Threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential for translational accuracy and fidelity. In human mitochondria, YrdC synthesises an l-threonylcarbamoyl adenylate (TC-AMP) intermediate, and OSGEPL1 transfers the TC-moiety to five tRNAs, including human mitochondrial tRNAThr (hmtRNAThr). Mutation of hmtRNAs, YrdC and OSGEPL1, affecting efficient t6A modification, has been implicated...

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Identifiers

PMID: 32047918
DOI: 10.1093/nar/gkaa093
PMCID: PMC7102964

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