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Article

METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs

2021-05-03

Abstract excerpt

A subset of eukaryotic tRNAs is methylated in the anticodon loop to form the 3-methylcytosine (m3C) modification. In mammals, the number of tRNAs containing m3C has expanded to include mitochondrial (mt) tRNA-Ser-UGA and mt-tRNA-Thr-UGU. Whereas the enzymes catalyzing m3C formation in nuclear-encoded cytoplasmic tRNAs have been identified, the proteins responsible for m3C modification in mt-tRNAs are unknown. Here...

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Literature Corpus work
efff8f6a-6306-57d5-9991-b06bc9765d65
DOI
10.1101/2021.05.02.442361
Open publication

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METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAsDOI 10.1101/2021.05.02.442361
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