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Article

Structural basis of 3'-tRNA maturation by the human mitochondrial RNase Z complex.

The EMBO journal - 1 Dec 2024

Valentín Gesé Genís, Hällberg B Martin

Abstract excerpt

Maturation of human mitochondrial tRNA is essential for cellular energy production, yet the underlying mechanisms remain only partially understood. Here, we present several cryo-EM structures of the mitochondrial RNase Z complex (ELAC2/SDR5C1/TRMT10C) bound to different maturation states of mitochondrial tRNAHis, showing the molecular basis for tRNA-substrate selection and catalysis. Our structural insights...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39516281
DOI: 10.1038/s44318-024-00297-w
PMCID: PMC11649783

Genes

ELAC2
TRMT10C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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