Article

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P

2020-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial diseases linked to mutations in mitochondrial(mt) tRNA sequences are abundant. However, the contributions of these tRNA mutations to the development of diseases is mostly unknown. Mutations may affect interactions with (mt)tRNA maturation enzymes or protein synthesis machinery leading to mitochondrial dysfunction. In human mitochondria, the first step of tRNA processing is the remo...

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Literature Corpus work: b9828fe6-ae28-5abc-acf7-9129c4f3f626
DOI: 10.1101/2020.07.07.191726

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