Article

Structural basis of 3′-tRNA maturation by the human mitochondrial RNAse Z complex

2024-05-14

Abstract excerpt

Human mitochondrial tRNA maturation is essential for cellular energy production, yet the underlying mechanisms remain only partially understood. Here, we present several cryo-EM structures of the mitochondrial RNase Z complex (ELAC2/SDR5C1/TRMT10C) bound to different maturation states of mitochondrial tRNA His , showing the molecular basis for tRNA-substrate selection and catalysis. Our structural insights provid...

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Literature Corpus work: 5499dc30-f594-574b-b5dd-cacddcc59d5c
DOI: 10.1101/2024.05.14.593974

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