Article
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.
Nature structural & molecular biology - 1 Oct 2009
Goto-Ito Sakurako, Ito Takuhiro, Kuratani Mitsuo, Bessho Yoshitaka, Yokoyama Shigeyuki
Abstract excerpt
tRNA precursors undergo a maturation process, involving nucleotide modifications and folding into the L-shaped tertiary structure. The N1-methylguanosine at position 37 (m1G37), 3' adjacent to the anticodon, is essential for translational fidelity and efficiency. In archaea and eukaryotes, Trm5 introduces the m1G37 modification into all tRNAs bearing G37. Here we report the crystal structures of archaeal Trm5...
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