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Haplotype-Resolved Genomics Reveals Conserved Chromatin Architecture and Epigenetic Constraints of Human Neocentromeres

2025-12-25

Abstract excerpt

Human neocentromeres are functional centromeres demarcated by CENP-A nucleosomes that form ectopically at alpha satellite-free loci. How neocentromeres reshape local chromatin and which features of native centromeric chromatin are preserved are unknown. We generated gapless, haplotype-resolved assemblies of native and neocentromeres from three patient-derived cell lines. Integrating CpG methylation, CENP-A profili...

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Literature Corpus work
dd3fe866-d49e-531a-b442-e7b1ea47a42b
DOI
10.64898/2025.12.23.696241
Open publication

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Haplotype-Resolved Genomics Reveals Conserved Chromatin Architecture and Epigenetic Constraints of Human NeocentromeresDOI 10.64898/2025.12.23.696241
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