Article
A Game of Thrones at Human Centromeres II. A new molecular/evolutionary model
2019-08-10
Abstract excerpt
Human centromeres are remarkable in four ways: they are i) defined epigenetically by an elevated concentration of the histone H3 variant CENP-A, ii) inherited epigenetically by trans-generational cary-over of nucleosomes containing CENP-A, iii) formed over unusually long and complex tandem repeats (Higher Order Repeats, HORs) that extend over exceptionally long arrays of DNA (up to 8 Mb), and iv) evolve in such a...
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Identifiers and source
- Literature Corpus work
- 8c81465d-5348-57a3-8245-5680534bb63f
- DOI
- 10.1101/731471