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Article

Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

13 Mar 2018

Abstract excerpt

ABSTRACT Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA methylation. Although much is known about DNA methylation establishment, DNA demethylation is less well understood. Recently, the Ten-Eleven Translocation proteins (TET1-3) have been...

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PMID: 29530881
DOI: 10.1242/dev.160622

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