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Article

TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency.

Stem cell reports - 9 Jan 2018

Tao Yu, Yen Ming-Ren, Chitiashvili Tsotne, Nakano Haruko, Kim Rachel, Hosohama Linzi, Tan Yao Chang, Nakano Atsushi, Chen Pao-Yang, Clark Amander T

Abstract excerpt

Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs). In mouse, ICR methylation and TE expression are each regulated by TRIM28; however, the role of TRIM28 in humans is less clear. Here, we show that a null mutation in TRIM28 causes significant alterations in TE expression in both the naive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29290627
DOI: 10.1016/j.stemcr.2017.11.020
PMCID: PMC5768987

Genes

TRIM28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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